Vasopressin Receptor V1a (AVR-V1a) Antibody from MyBioSource.com

Rat AVR-V1a receptor is a G-protein coupled membrane protein with seven transmembrane domains. N-terminus is predicted to be extracellular. Vasopressin (AVP, Arginine-8-Vasopressin), the antidiuretic hormone is cyclic nonapeptide involved in the homeostasis of body fluid osmolality, blood volume, vascular tone, and blood pressure. Specific actions of AVP include inhibition of diuresis, contraction of smooth muscle, stimulation of liver glycogenesis, and modulation of ACTH release from pituitary. AVP belongs to the family of vasoactive and mitogenic peptides involved in normal and pathological cell growth and differentiation. AVP exerts its action through binding to specific membrane receptors coupled to distinct second messengers. There are 3 types of AVP receptors: V1a, V1b, and V2 subtypes. The V2 receptor stimulates adenyl cyclase and protein Kinase A, V1 activate phospholipase A2.C, and D, resulting into production of IP3 and DAG, the mobilization of intracellular calcium, the influx of extracellular calcium, the activation of protein Kinase C, and protein phosphorylation